GEN-3a: Uw=G alias, second spotting locus Sls (SlSl lethal), Sp×Sls Superschecke, flag/metadata token tolerance (dea/WFNZ/DP/RV/GV)
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@@ -64,18 +64,28 @@ export function makeGenotype(input: Record<LocusKey, AllelePair>): Genotype {
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export function wildType(): Genotype {
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const out = {} as Record<LocusKey, AllelePair>
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for (const locus of LOCUS_ORDER) {
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// Wild-type is homozygous for the most dominant allele, EXCEPT the
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// marker loci Sp/Re whose wild form is the recessive (unmarked) allele.
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// Wild-type is homozygous for the most dominant allele, EXCEPT the marker
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// loci Sp/Re/Sls whose wild form is the recessive (unmarked) allele.
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const alleles = LOCI[locus].alleles
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const a = locus === 'Sp' || locus === 'Re' ? alleles[alleles.length - 1] : alleles[0]
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const marker = locus === 'Sp' || locus === 'Re' || locus === 'Sls'
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const a = marker ? alleles[alleles.length - 1] : alleles[0]
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out[locus] = [a, a]
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}
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return out
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}
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/** Compact display string, e.g. "Aa CC Dd EE GG Pp spsp rere". */
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/**
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* Compact display string, e.g. "Aa CC Dd EE GG Pp spsp rere".
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* The Sls locus is OMITTED when wild-type (sl/sl) so legacy 8-locus strings and
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* the colour catalog stay byte-identical; it only appears for WP/Sls carriers
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* (e.g. "… spsp rere Slsl"). Round-trips: a missing Sls re-parses to sl/sl.
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*/
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export function toDisplayString(g: Genotype): string {
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return LOCUS_ORDER.map((locus) => g[locus][0] + g[locus][1]).join(' ')
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return LOCUS_ORDER.filter(
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(locus) => locus !== 'Sls' || !(g.Sls[0] === 'sl' && g.Sls[1] === 'sl'),
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)
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.map((locus) => g[locus][0] + g[locus][1])
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.join(' ')
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}
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/** Stable JSON-storable object (already the in-memory shape; returned as a copy). */
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@@ -114,14 +124,72 @@ function splitToken(token: string): [string, string] {
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}
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/**
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* Parse a display string ("Aa CC Dd EE GG Pp Spsp rere") back into a Genotype.
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* Tokens may be given in any order; each token must belong to a distinct locus.
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* GEN-3a: tokens that are NOT genotype loci — health/provenance metadata that may
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* appear in a herd-book genotype string. Stripped on parse (see extractGenotypeFlags).
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* - dea/Dea/taub = deafness flag (after spsp); DP/DarkPatch = non-Mendelian patch flag
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* - WFNZ/RV/GV = provenance/breeding-method annotations
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*/
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const FLAG_TOKENS = new Set(['DP', 'DarkPatch', 'dea', 'Dea', 'taub', 'WFNZ', 'RV', 'GV'])
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/**
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* Normalize one whitespace-token to canonical allele symbols, or null if it is a
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* non-genotype flag/metadata token (to be stripped):
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* - Uw/uw -> G/g (international Underwhite == German Grey locus)
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* - S(l)/s(l) -> Sl/sl (second spotting locus notation)
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* - WP -> Slsl (WP is the visible S(l)s(l) heterozygote)
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*/
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function normalizeToken(tok: string): string | null {
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if (FLAG_TOKENS.has(tok)) return null
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let t = tok
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if (t === 'WP') t = 'Slsl'
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t = t.replace(/S\(l\)/g, 'Sl').replace(/s\(l\)/g, 'sl')
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t = t.replace(/Uw/g, 'G').replace(/uw/g, 'g')
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return t
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}
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/**
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* Canonical normalized genotype string (flags/metadata removed, Uw/S(l)/WP
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* resolved). Exported so the import pipeline (GEN-3b) can mirror this exactly.
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*/
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export function normalizeGenotypeString(input: string): string {
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return input
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.trim()
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.split(/\s+/)
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.filter(Boolean)
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.map(normalizeToken)
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.filter((t): t is string => t !== null)
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.join(' ')
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}
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/**
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* Extract non-Punkett flags from a raw genotype string: deafness (dea/taub =
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* deaf, Dea = hearing) and provenance/pattern tags (WFNZ/RV/GV/DP).
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*/
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export function extractGenotypeFlags(input: string): { deaf?: boolean; tags: string[] } {
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const tokens = input.trim().split(/\s+/).filter(Boolean)
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let deaf: boolean | undefined
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const tags: string[] = []
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for (const tok of tokens) {
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if (tok === 'dea' || tok === 'taub') deaf = true
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else if (tok === 'Dea') deaf = false
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else if (tok === 'DP' || tok === 'DarkPatch' || tok === 'WFNZ' || tok === 'RV' || tok === 'GV')
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tags.push(tok)
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}
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return { deaf, tags }
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}
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/**
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* Parse a display string ("Aa CC Dd EE GG Pp Spsp rere [Slsl]") back into a
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* Genotype. Tokens may be in any order; each must belong to a distinct locus.
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* Uw/S(l)/WP are normalized and flag/metadata tokens (dea, WFNZ, …) are stripped.
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* Missing loci default to wild-type.
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*/
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export function fromDisplayString(input: string): Genotype {
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const tokens = input.trim().split(/\s+/).filter(Boolean)
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const acc = {} as Record<LocusKey, AllelePair>
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for (const token of tokens) {
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for (const raw of tokens) {
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const token = normalizeToken(raw)
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if (token === null) continue // flag/metadata token — not a locus
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const [a, b] = splitToken(token)
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const refAllele = a === WILDCARD ? b : a
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if (refAllele === WILDCARD) {
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@@ -25,6 +25,7 @@ interface LethalRule {
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const LETHAL_RULES: readonly LethalRule[] = [
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{ locus: 'Sp', allele: 'Sp', kind: 'lethal', warning: GeneticsWarningCode.ScheckeLethal },
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{ locus: 'Sls', allele: 'Sl', kind: 'lethal', warning: GeneticsWarningCode.SlsLethal },
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{ locus: 'Re', allele: 'Re', kind: 'semi', warning: GeneticsWarningCode.RexSemiLethal },
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]
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@@ -67,14 +68,23 @@ export function applyLethality(dist: DistEntry<Genotype>[]): LethalityResult {
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? survivors
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: survivors.map((e) => ({ value: e.value, probability: divide(e.probability, survivingMass) }))
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if (lethalMass.num > 0) {
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warnings.push({
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code: GeneticsWarningCode.ScheckeLethal,
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detail: {
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youngLostFraction: toString(lethalMass),
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youngLostPercent: Number(((lethalMass.num / lethalMass.den) * 100).toFixed(2)),
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},
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})
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// One lethal warning PER lethal rule that actually removed young (so SpSp ->
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// ScheckeLethal and S(l)S(l) -> SlsLethal are reported distinctly).
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for (const rule of LETHAL_RULES) {
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if (rule.kind !== 'lethal') continue
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const mass = dist.reduce<Fraction>(
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(acc, e) => (isHomozygous(e.value, rule.locus, rule.allele) ? add(acc, e.probability) : acc),
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ZERO,
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)
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if (mass.num > 0) {
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warnings.push({
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code: rule.warning,
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detail: {
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youngLostFraction: toString(mass),
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youngLostPercent: Number(((mass.num / mass.den) * 100).toFixed(2)),
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},
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})
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}
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}
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// Semi-lethal: warn if any surviving genotype is homozygous for a semi-lethal allele.
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@@ -95,5 +105,22 @@ export function applyLethality(dist: DistEntry<Genotype>[]): LethalityResult {
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}
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}
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// Superschecke: surviving young carrying BOTH spotting markers (Sp present and
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// S(l) present) are very-high-white and deafness-prone — info warning.
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const superMass = distribution.reduce<Fraction>((acc, e) => {
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const hasSp = e.value.Sp.includes('Sp')
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const hasSl = e.value.Sls.includes('Sl')
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return hasSp && hasSl ? add(acc, e.probability) : acc
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}, ZERO)
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if (superMass.num > 0) {
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warnings.push({
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code: GeneticsWarningCode.SuperscheckeDeaf,
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detail: {
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affectedFraction: toString(superMass),
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affectedPercent: Number(((superMass.num / superMass.den) * 100).toFixed(2)),
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},
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})
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}
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return { distribution, warnings }
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}
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@@ -12,8 +12,12 @@
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* - de.wikibooks.org/wiki/Die_Rennmaus/_Farbvarianten_und_Farbgenetik
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*/
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/** Canonical locus keys, in conventional display order. */
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export const LOCUS_ORDER = ['A', 'C', 'D', 'E', 'G', 'P', 'Sp', 'Re'] as const
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/**
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* Canonical locus keys, in conventional display order. Sls (second spotting
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* locus) is appended LAST so legacy 8-locus genotype strings still parse — a
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* missing Sls token defaults to wild-type sl/sl.
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*/
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export const LOCUS_ORDER = ['A', 'C', 'D', 'E', 'G', 'P', 'Sp', 'Re', 'Sls'] as const
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export type LocusKey = (typeof LOCUS_ORDER)[number]
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export interface LocusDef {
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@@ -33,9 +37,12 @@ export interface LocusDef {
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* E = full extension
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* ef = Schimmel/roan (progressive whitening)
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* e = Fox (suppresses eumelanin)
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* Sp/Re are dominant markers, lethal/semi-lethal when homozygous (see lethality.ts):
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* Sp = Schecke (checkered); checkered animals are always Spsp, SpSp dies in utero.
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* Re = Rex (curly coat); rex animals are Re-, ReRe is semi-lethal.
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* Sp/Re/Sls are dominant markers, lethal/semi-lethal when homozygous (see lethality.ts):
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* Sp = Schecke (checkered); checkered animals are always Spsp, SpSp dies in utero.
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* Re = Rex (curly coat); rex animals are Re-, ReRe is semi-lethal.
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* Sls = second spotting locus (S(l), WP/Minimalschecke). S(l)s(l) het = the WP
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* phenotype; S(l)S(l) homozygous = lethal (Rumpback/megacolon). Sp + Sls
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* together => Superschecke (very high white, deafness-prone).
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*/
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export const LOCI: Readonly<Record<LocusKey, LocusDef>> = {
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A: { key: 'A', nameDe: 'Agouti', alleles: ['A', 'a'] },
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@@ -46,6 +53,7 @@ export const LOCI: Readonly<Record<LocusKey, LocusDef>> = {
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P: { key: 'P', nameDe: 'Rotaugenaufhellung (Pink-Eye)', alleles: ['P', 'p'] },
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Sp: { key: 'Sp', nameDe: 'Schecke', alleles: ['Sp', 'sp'] },
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Re: { key: 'Re', nameDe: 'Rex', alleles: ['Re', 're'] },
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Sls: { key: 'Sls', nameDe: 'Zweite Scheckung (WP)', alleles: ['Sl', 'sl'] },
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}
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/** Set of all valid allele symbols, longest-first (for maximal-munch parsing). */
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@@ -10,6 +10,10 @@ export const GeneticsWarningCode = {
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ScheckeLethal: 'SCHECKE_LETHAL',
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/** Rex × Rex: ReRe is semi-lethal; reduced viability of homozygous young. */
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RexSemiLethal: 'REX_SEMI_LETHAL',
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/** WP × WP: S(l)S(l) is prenatal-lethal (Rumpback/megacolon); fewer live young. */
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SlsLethal: 'SLS_LETHAL',
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/** Sp + Sls together -> Superschecke: very high white, deafness-prone (info). */
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SuperscheckeDeaf: 'SUPERSCHECKE_DEAF',
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} as const
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export type GeneticsWarningCode =
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